Invited Commentary: Exposure Biomarkers Indicate More Than Just Exposure

Invited commentary: interpreting associations between exposure biomarkers and pregnancy outcome.

Levels of exposure biomarkers vary among individuals because of differences in both environmental exposure and metabolism. However, the ultimate interest is in providing information about the impact of modifying environmental exposures through regulation or behavior change. Using these levels in studies of pregnancy outcomes, as nicely illustrated by the study of Kadhel et al. in this issue of ...

Full Review Biomarkers: more than just markers!*

In the strive for optimal indicators of kidney damage, nephrologists may at times feel entangled in a molecular jungle. Contrary to cardiologists that succeeded in establishing highly sensitive biomarker molecules for hypoxic cellular damage, nephrologists await well-performing ‘damage’ indicators. Reasons for this are ample and mostly relate to the complex composition of the functional units a...

Invited commentary: the action in the interaction and exposure modification.

The study of disease variability in populations is a goal of modern epidemiology. Because most common diseases arise out of a combination of factors and events (exposures, heritability, comorbidities, and chance), developing simple models of characterizing joint events is a daunting task. Dr. Weinberg argues successfully in this issue of the Journal (Am J Epidemiol. 2012;175(7):602-605) that ad...

More than "just do it"-fear-based exposure for complex regional pain syndrome.

Complex regional pain syndrome (CRPS) is difficult to treat, no matter what your treatment approach. Of the 25 pharmacological, interventionist, exercise, and alternative therapy approaches that have been systematically reviewed, only a few have any promise and even those “may” be helpful. Clinical guidelines reflect this underwhelming situation—recommendations to promote function, to include “...

More than just vanilla.